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Nighttime Cough Medicine

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CVS Health
$7.29
91.1¢/oz.
ExtraCare Plus price$5.83
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Nighttime Cold Medicine for Multi-Symptom Relief 

Nighttime cold medicine relieves the symptoms associated with the common cold, influenza and other respiratory illnesses. Each brand has a different formula, but the active ingredients usually help alleviate symptoms such as coughing, sneezing and aching joints. Shop the CVS online store to find the right cold medicine for your needs. 

What are the Best Nighttime Cough Medicine Brands?

Common Ingredients in Nighttime Cold Medicine

Some of the most common nighttime cold medicine ingredients include: 

  • Acetaminophen 

  • Diphenhydramine 

  • Doxylamine succinate 

  • Dextromethorphan HBr 

Acetaminophen is an over-the-counter pain reliever that may ease the aches and pains associated with colds, flu and other illnesses. Diphenhydramine is an antihistamine, a medication used to treat allergy symptoms. Cold medications with diphenhydramine may help with symptoms such as sneezing, itchy eyes and runny nose. Doxylamine succinate is also an antihistamine, so it treats the same symptoms. 

Finally, dextromethorphan HBr is a common ingredient in nighttime cough medicine. It treats unproductive cough, or a cough that doesn't produce phlegm. Dextromethorphan is designed for short-term use, not for chronic coughs caused by emphysema, chronic obstructive pulmonary disease or other long-term medical conditions. 

Does Nighttime Cold Medicine Make You Sleepy?

If your cold medication contains an antihistamine medication, such as diphenhydramine or doxylamine succinate, it may make you sleepy. Therefore, these ingredients may help you get much-needed rest when you're sick, but avoid driving, operating heavy machinery or performing other activities that require you to be awake and alert when taking medicines containing these ingredients. 

How Long Does Nighttime Cold Medicine Last?

It depends on which medication you take. Some nighttime cold medicines wear off after 4 hours, while others last 6 hours or more. Read the label carefully to determine how often to take your preferred medication.  

What Is the Best Nighttime Cough Medicine?

If you're looking for the best nighttime cough medicine, choose something formulated to treat your symptoms. For example, if you have a cough and a fever, you may need cold medication with a cough suppressant and a fever reducer

Also, avoid ingredients that are likely to keep you awake instead of helping you sleep. Some cold medications contain decongestants, which may make you feel wired. If you have heart disease, high blood pressure or another chronic health condition, seek advice from your health care professional before choosing a nighttime cold or cough medication.